栄養化学分野 タイトル Last update
2022.4.1
Japanese
List of Publications in English
*corresponding author

Tsutomu SASAKI ORCID 0000-0001-8041-1915
Satoshi TSUZUKI ORCID 0000-0003-4385-0075
Sho MATSUI ORCID 0000-0003-1256-1182
Yasuo OGURI ORCID 0000-0002-7435-6961

 
2022
Application of a novel fluorescence intensity assay: identification of distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of a transmembrane receptor CD36.
*Tsuzuki S, Kimoto Y, Marui K, Lee S, Inoue K, Sasaki T.
Biosci Biotechnol Biochem. 2022 Mar 21;86(4):509-518. doi: 10.1093/bbb/zbac018. PMID: 35102395

Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium.
Kim TH, Young SL, Sasaki T, Deaton JL, Schammel DP, Palomino WA, Jeong JW, Lessey BA.
J Clin Endocrinol Metab. 2022 Feb 17 ;107(3):788-800. doi: 10.1210/clinem/dgab753. PMID: 34665857

The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic-Pituitary-Thyroid Axis for Regulating Thyroid Hormone Levels.
Kondo Y, Ozawa A, Kohno D, Saito K, Buyandalai B, Yamada S, Horiguchi K, Nakajima Y, Shibusawa N, Harada A, Yokoo H, Akiyama H, Sasaki T, Kitamura T, Yamada M*.
Thyroid. 2022 Jan;32(1):105-114. doi: 10.1089/thy.2021.0444.
PMID: 34726513

2021
Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore.
*Tsuzuki S, Kimoto Y, Yamasaki M, Sugawara T, Manabe Y, Inoue K, Sasaki T.
Biomed Res. 2021;42(5):181-191. doi: 10.2220/biomedres.42.181.
PMID: 34544994

Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.
Kawakami R, Matsui M, Konno A, Kaneko R, Shrestha S, Shrestha S, Sunaga H, Hanaoka H, Goto S, Hosojima M, Kabasawa H, Obokata M, Koitabashi N, Matsui H, Sasaki T, Saito A, Yanagita M, Hirai H, Kurabayashi M, Iso T.
J Pathol. 2021 Dec;255(4):362-373. doi: 10.1002/path.5775.
PMID: 34370295

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database.
Minamino H, Katsushima M, Hashimoto M, Fujita Y, Torii M, Ikeda K, Isomura N, Oguri Y, Yamamoto W, Watanabe R, Murakami K, Murata K, Nishitani K, Tanaka M, Ito H, Uda M, Nin K, Arai H, Matsuda S, Morinobu A, Inagaki N.
PLoS One. 2021 Aug 5;16(8):e0255526. doi: 10.1371/journal.pone.0255526. eCollection 2021.
PMID: 34351967

Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.
Wada E, Kobayashi M, Kohno D, Kikuchi O, Suga T, Matsui S, Yokota-Hashimoto H, Honzawa N, Ikeuchi Y, Tsuneoka H, Hirano T, Obinata H, Sasaki T, Kitamura T.
J Nutr Biochem. 2021 Jun 28;97:108811. doi: 10.1016/j.jnutbio.2021.108811.
PMID: 34197915

Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study.
Minamino H, Katsushima M, Hashimoto M, Fujita Y, Yoshida T, Ikeda K, Isomura N, Oguri Y, Yamamoto W, Watanabe R, Murakami K, Murata K, Nishitani K, Tanaka M, Ito H, Ohmura K, Matsuda S, Inagaki N, Morinobu A.
Arthritis Res Ther. 2021 Mar 27;23(1):96. doi: 10.1186/s13075-021-02479-x.
PMID: 33773587

microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K.
Nat Commun. 2021 Feb 16;12(1):843. doi: 10.1038/s41467-021-21107-5.
PMID:33594062

The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D.
Nat Metab. 2021 Feb;3(2):244-257. doi: 10.1038/s42255-021-00349-z.
PMID: 33619378

2020
Blood-cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA.
Ngo-Thanh H, Sasaki T, Suzue K, Yokoo H, Isoda K, Kamitani W, Shimokawa C, Hisaeda H, Imai T.
Int J Parasitol. 2020 Dec;50(14):1167-1175. doi: 10.1016/j.ijpara.2020.07.007.
PMID:32882285

The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication.
Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S.
EMBO Rep. 2020 Sep 3;21(9):e49828. doi: 10.15252/embr.201949828.
PMID: 32672883

TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis.
Damal Villivalam S, You D, Kim J, Lim HW, Xiao H, Zushin PH, Oguri Y, Amin P, Kang S.
Nat Commun. 2020 Aug 27;11(1):4313. doi: 10.1038/s41467-020-18054-y.
PMID: 32855402

Leukotriene A 4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Jo-Watanabe A, Kazuno S, Miyatsuka T, Kitamura T, Fujitani Y, Watada H, Saeki K, Yokomizo T.
FASEB J. 2020 Aug 26. doi: 10.1096/fj.202001148R.
PMID:32844470

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis.
Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S.
Nat Commun. 2020 Apr 7;11(1):1730. doi: 10.1038/s41467-020-15589-y.
PMID: 32265443

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S.
Cell. 2020 Aug 6;182(3):563-577.e20. doi: 10.1016/j.cell.2020.06.021.
PMID: 32615086

The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis.
Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W.
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11674-11684. doi: 10.1073/pnas.1921015117. Epub 2020 May 11.
PMID: 32393635

Cellular heterogeneity in brown adipose tissue.
Oguri Y, Kajimura S.
J Clin Invest. 2020 Jan 2;130(1):65-67. doi: 10.1172/JCI133786. Review
PMID: 31763995

2019
Higher straight-chain aliphatic aldehydes: Importance as odor-active volatiles in human foods and issues for future research.
*Tsuzuki S.
J Agric Food Chem. 2019 May 1;67(17):4720-4725. doi: 10.1021/acs.jafc.9b01131.
PMID: 30945546

SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels.
Suga T, Kikuchi O, Kobayashi M, Matsui S, Yokota-Hashimoto H, Wada E, Kohno D, Sasaki T, Takeuchi K, Kakizaki S, Yamada M, Kitamura T.
Mol Metab. 2019 Jan;19:1-12. doi: 10.1016/j.molmet.2018.10.009.
PMID: 30416006

2018
Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice.
Matsui S, *Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T.
Nat Commun. 2018 Nov 2;9(1):4604. doi: 10.1038/s41467-018-07033-z.
PMID: 30389922

Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance.
Gulshan M, Yaku K, Okabe K, Mahmood A, Sasaki T, Yamamoto M, Hikosaka K, Usui I, Kitamura T, Tobe K, Nakagawa T.
Aging Cell. 2018 Jun 14:e12798. doi: 10.1111/acel.12798. [Epub ahead of print]
PMID: 29901258

A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice.
*Sasaki T, Numano R, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T.
Mol Brain. 2018 May 24;11(1):28. doi: 10.1186/s13041-018-0372-9.
PMID: 29793524

A role for scavenger receptor B1 as a captor of specific fatty acids in taste buds of circumvallate papillae.
*Tsuzuki S, Lee S, Kimoto Y, Sugawara T, Manabe Y, Inoue K.
Biomed Res. 2018;39(6):295-300. doi: 10.2220/biomedres.39.295.
PMID: 30531159

A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity.
*Tsuzuki S, Kimoto Y, Lee S, Sugawara T, Manabe Y, Inoue K.
Biomed Res. 2018;39(3):117-129. doi: 10.2220/biomedres.39.117.
PMID: 29899187

2017
Intraperitoneal injection of d-serine inhibits high-fat diet intake and preference in male mice.
*Sasaki T, Yasoshima Y, Matsui S, Yokota-Hashimoto H, Kobayashi M, Kitamura T.
Appetite. 2017 Nov 1;118:120-128. doi: 10.1016/j.appet.2017.08.011.
PMID: 28803978

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.
Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
PLoS Genet. 2017 Aug 30;13(8):e1006950. doi: 10.1371/journal.pgen.1006950.
PMID: 28854265

Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
Iwakoshi-Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, Sasaki T, Okamoto S, Bentley GE, Kriegsfeld LJ, Minokoshi Y, Ukena K.
Elife. 2017 Aug 11;6. pii: e28527. doi: 10.7554/eLife.28527.
PMID: 28799896

Expanding frontiers in weight-control research explored by young investigators.
Ishimaru Y, Kozuka C, Nakajima K, *Sasaki T.
J Physiol Sci. 2017 Jan;67(1):83-95. doi: 10.1007/s12576-016-0495-7. Review.
PMID: 27730500

A search for CD36 ligands from flavor volatiles in foods with an aldehyde moiety: identification of saturated aliphatic aldehydes with 9-16 carbon atoms as potential ligands of the receptor.
*Tsuzuki S, Amitsuka T, Okahashi T, Kimoto Y, Inoue K.
J Agric Food Chem. 2017 Aug 9;65(31):6647-6655. doi: 10.1021/acs.jafc.7b01890.
PMID: 28682068

CD36 involvement in the olfactory perception of oleic aldehyde, an odour-active volatile compound, in mice.
Lee S, *Tsuzuki S, Amitsuka T, Masuda D, Yamashita S, Inoue K.
Biomed Res. 2017;38(3):207-213. doi: 10.2220/biomedres.38.207.
PMID: 28637956

Assessment of direct interaction between CD36 and an oxidized glycerophospholipid species.
*Tsuzuki S, Yamasaki M, Kozai Y, Sugawara T, Manabe Y, Inoue K, Fushiki T.
J Biochem. 2017 Sep 1;162(3):163-172. doi: 10.1093/jb/mvx019.
PMID: 28338861

2016
Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.
*Sasaki T, Matsui S, Kitamura T.
Int J Mol Sci. 2016 Jul 7;17(7). pii: E1081. doi: 10.3390/ijms17071081. Review.
PMID: 27399680

Identification of the odor-active volatile compound (Z,Z)-4,7-tridecadienal as a potential ligand for the transmembrane receptor CD36.
*Tsuzuki S, Amitsuka T, Okahashi T, Kozai Y, Yamasaki M, Inoue K, Fushiki T.
Biomed Res. 2016;37(6):335-342. doi: 10.2220/biomedres.37.335.
PMID: 28003580

Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin.
Zheng M, Lee S, Tsuzuki S, Inoue K, Masuda D, Yamashita S, Iwanaga T.
Biomed Res. 2016;37(4):265-70. doi: 10.2220/biomedres.37.265.
PMID: 27545003

A single aldehyde group can serve as a structural element for recognition by transmembrane protein CD36.
*Tsuzuki S, Amitsuka T, Okahashi T, Kozai Y, Matsumura S, Inoue K, Fushiki T.
Biosci Biotechnol Biochem. 2016 Jul;80(7):1375-8. doi: 10.1080/09168451.2016.1151343.
PMID: 26923548

2015
Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity.
*Sasaki T.
Front Endocrinol (Lausanne). 2015 Jul 16;6:109. doi: 10.3389/fendo.2015.00109. Review.
PMID: 26236282

N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food.
*Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T.
Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R561-75. doi: 10.1152/ajpregu.00083.2015.
PMID: 26157056

Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice.
Sasaki T, Kuroko M, Sekine S, Matsui S, Kikuchi O, Susanti VY, Kobayashi M, Tanaka Y, Yuasa T, Kitamura T.
Endocr J. 2015;62(9):787-96. doi: 10.1507/endocrj.EJ15-0255.
PMID: 26096452

Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue.
Sasaki T, Hiraga H, Yokota-Hashimoto H, Kitamura T.
Endocr J. 2015;62(5):469-73. doi: 10.1507/endocrj.EJ15-0116.
PMID: 25833077

A role of CD36 in the perception of an oxidised phospholipid species in mice.
Lee S, Eguchi A, Sakamoto K, Matsumura S, *Tsuzuki S, Inoue K, Masuda D, Yamashita S, Fushiki T.
Biomed Res. 2015;36(5):303-11. doi: 10.2220/biomedres.36.303.
PMID: 26522147

Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration.
Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Lee S, Adachi S, Fujitani M, Tsuzuki S, Inoue K, Fushiki T.
J Nutr Sci Vitaminol (Tokyo). 2015;61(3):247-54. doi: 10.3177/jnsv.61.247.
PMID: 26226962

Expression of CD36 by Olfactory Receptor Cells and Its Abundance on the Epithelial Surface in Mice.
Lee S, Eguchi A, *Tsuzuki S, Matsumura S, Inoue K, Iwanaga T, Masuda D, Yamashita S, Fushiki T.
PLoS One. 2015 Jul 17;10(7):e0133412. doi: 10.1371/journal.pone.0133412.
PMID: 26186589

The opioid system contributes to the acquisition of reinforcement for dietary fat but is not required for its maintenance.
Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Yoneda T, Mizushige T, Tsuzuki S, Inoue K, Fushiki T.
Physiol Behav. 2015 Jan;138:227-35. doi: 10.1016/j.physbeh.2014.11.001.
PMID: 25446206

2014
Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.
Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK.
J Neurosci. 2014 Nov 12;34(46):15288-96. doi: 10.1523/JNEUROSCI.1316-14.2014.
PMID: 25392496

Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice.
Susanti VY, *Sasaki T, Yokota-Hashimoto H, Matsui S, Lee YS, Kikuchi O, Shimpuku M, Kim HJ, Kobayashi M, Kitamura T.
Obesity (Silver Spring). 2014 Oct;22(10):2115-9. doi: 10.1002/oby.20838.
PMID: 25044690

Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
Yoshino S, Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano-Toki A, Kakizaki S, Okada S, Shimizu H, Ozawa A, Tuchiya T, Ikota H, Nakazato Y, Mori M, Matozaki T, Sasaki T, Kitamura T, Mori M.
Endocrinology. 2014 Sep;155(9):3459-72. doi: 10.1210/en.2013-2160.
PMID: 25004093

Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice.
Usui T, Kajita K, Kajita T, Mori I, Hanamoto T, Ikeda T, Okada H, Taguchi K, Kitada Y, Morita H, Sasaki T, Kitamura T, Sato T, Kojima I, Ishizuka T.
FEBS Lett. 2014 May 21;588(10):1935-41. doi: 10.1016/j.febslet.2014.03.051.
PMID: 24726723

Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
*Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T.
Diabetologia. 2014 Apr;57(4):819-31. doi: 10.1007/s00125-013-3140-5.
PMID: 24374551

ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription.
Lee YS, Kobayashi M, Kikuchi O, Sasaki T, Yokota-Hashimoto H, Susanti VY, Ido Kitamura Y, Kitamura T.
Endocr J. 2014;61(1):85-90.
PMID: 24140652

Further validation of unsaturated long-chain fatty acids as inhibitors for oxidized low-density lipoprotein binding to CD36 via assays with synthetic CD36 peptide-cross-linked plates.
Kozai Y, *Tsuzuki S, Takai M, Eguchi A, Matsumura S, Inoue K, Fushiki T.
Biosci Biotechnol Biochem. 2014;78(5):839-42. doi: 10.1080/09168451.2014.891934.
PMID: 25035987

Unsaturated long-chain fatty acids inhibit the binding of oxidized low-density lipoproteins to a model CD36.
Takai M, Kozai Y, *Tsuzuki S, Matsuno Y, Fujioka M, Kamei K, Inagaki H, Eguchi A, Matsumura S, Inoue K, Fushiki T.
Biosci Biotechnol Biochem. 2014;78(2):238-44. doi: 10.1080/09168451.2014.882750.
PMID: 25036676

A study of an aroma extraction method and evaluation of the aroma extract contribution to the palatability and reinforcement effect of dried bonito using mice.
Amitsuka T, Okamura M, Shiibashi H, Yamamoto N, Saito T, Nammoku T, Tsuzuki S, Inoue K, Fushiki T.
J Nutr Sci Vitaminol (Tokyo). 2014;60(5):328-33. doi: 10.3177/jnsv.60.328.
PMID: 25744421

Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells.
Adachi S, Eguchi A, Sakamoto K, Asano H, Manabe Y, Matsumura S, Tsuzuki S, Inoue K, Fushiki T.
Biomed Res. 2014;35(6):357-67. doi: 10.2220/biomedres.35.357.
PMID: 25743342


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