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Topics of interests
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Homeostatic reguation of nutritional preference
We are interested in elucidating the mechanisms that regulate eating behavior at sub-conscious level. Specifically, we are interested in "what we eat (eating-related decision making)", rather than "how much we eat (regulating of caloric intake)."
We focus on the homeostatic regulation of nutritional preference. In other words, we are interested in eating-related decision making based on the nutritional needs.
We recently elucidated a part of the mechanisms that regulates simple sugar preference（Matsui, Sasaki* et al., Nature Communications, 2018; Mori, ..., Sasaki*. Am J Physiol Endocrinology and Metabolism, 2025）. We are currently working on identifying the mechnism that regulate preferences for fat and protein.
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Neurocircuits that regulates food preference
We established a pharmacological model, in which food preference is reversibly altered in a nutrition-independent manner（Sasaki* et al., American Journal of Physiology, 2015）. We are utilizing this unusual model for exploring the neurocircuits that regulate food preference at the whole brain scale.
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| Techniques you can lab in the lab
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Neuroscience: stereotaxic surgery, virus vector production, histology
Endocrinology and Metabolism: concepts in hormone and multi-organ system
Molecular Biology; DNA, RNA, protein, cell cultue, signaling experiments
Genetics: how to use genetically modified mice
etc.
Tsutomu Sasaki, MD/PhD, Professor of Nutrition Chemistry
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